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- Three-Year Survival 15 percent
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- Investigational
- • Radiation given during the operation— intraoperative radiotherapy (IORT)—is being evaluated.
- • Some trials of split course radiotherapy of 4,000 to 6,000 cGy over six to eight weeks have shown one-year
- survival of 34 percent and five-year survival of 20 percent.
- • Brachytherapy—implanting irradiating seeds of radon or boron—is under clinical evaluation at a few centers.
- Results so far have not been promising.
- • Postoperative large-field radiation with 5-FU chemotherapy is also being evaluated and it appears that this
- combination improves survival. Side effects include diarrhea, inflammation of the intestinal lining and liver
- toxicity.
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- Stage II
- TNM T3, N0, M0
- The cancer has directly spread to involve adjacent organs such as the stomach, spleen or colon.
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